By the River Piedra I Sat Down and Wept tells of Pilar, a frustrated scholar looking for some greater meaning in the endless cycle of her days. When a childhood friend contacts her, she is surprised to learn that her former playmate is now a charismatic spiritual leader, someone revered as a miracle worker. She is even more astonished when he reveals that Pilar has always been his great love. Confused by this sudden opportunity for a new chance at life, Pilar gradually comes to realise that the man she loves is being called upon to choose between her and his spiritual calling.